Gastrointestinal dysfunction in Parkinson's disease.
Identifieur interne : 000718 ( Main/Exploration ); précédent : 000717; suivant : 000719Gastrointestinal dysfunction in Parkinson's disease.
Auteurs : Alfonso Fasano [Canada] ; Naomi P. Visanji [Canada] ; Louis W C. Liu [Canada] ; Antony E. Lang [Canada] ; Ronald F. Pfeiffer [États-Unis]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- complications : Gastrointestinal Diseases.
- drug therapy : Gastrointestinal Diseases, Parkinson Disease.
- epidemiology : Gastrointestinal Diseases, Parkinson Disease.
- etiology : Parkinson Disease.
- Comorbidity, Humans.
Abstract
Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's disease has increased substantially in the past decade. The entire gastrointestinal tract is affected in these patients, causing complications that range from oral issues, including drooling and swallowing problems, to delays in gastric emptying and constipation. Additionally, small intestinal bacterial overgrowth and Helicobacter pylori infection affect motor fluctuations by interfering with the absorption of antiparkinsonian drugs. The multifaceted role of the gastrointestinal system in Parkinson's disease necessitates a specific and detailed assessment and treatment plan. The presence of pervasive α-synuclein deposition in the gastrointestinal tract strongly implicates this system in the pathogenesis of Parkinson's disease. Future studies elucidating the role of the gastrointestinal tract in the pathological progression of Parkinson's disease might hold potential for early disease detection and development of neuroprotective approaches.
DOI: 10.1016/S1474-4422(15)00007-1
PubMed: 25987282
Affiliations:
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Le document en format XML
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Electronic address: alfonso.fasano@uhn.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Visanji, Naomi P" sort="Visanji, Naomi P" uniqKey="Visanji N" first="Naomi P" last="Visanji">Naomi P. Visanji</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Louis W C" sort="Liu, Louis W C" uniqKey="Liu L" first="Louis W C" last="Liu">Louis W C. Liu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology, Department of Medicine, Toronto Western Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Gastroenterology, Department of Medicine, Toronto Western Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Antony E" sort="Lang, Antony E" uniqKey="Lang A" first="Antony E" last="Lang">Antony E. Lang</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Pfeiffer, Ronald F" sort="Pfeiffer, Ronald F" uniqKey="Pfeiffer R" first="Ronald F" last="Pfeiffer">Ronald F. Pfeiffer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. 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The entire gastrointestinal tract is affected in these patients, causing complications that range from oral issues, including drooling and swallowing problems, to delays in gastric emptying and constipation. Additionally, small intestinal bacterial overgrowth and Helicobacter pylori infection affect motor fluctuations by interfering with the absorption of antiparkinsonian drugs. The multifaceted role of the gastrointestinal system in Parkinson's disease necessitates a specific and detailed assessment and treatment plan. The presence of pervasive α-synuclein deposition in the gastrointestinal tract strongly implicates this system in the pathogenesis of Parkinson's disease. Future studies elucidating the role of the gastrointestinal tract in the pathological progression of Parkinson's disease might hold potential for early disease detection and development of neuroprotective approaches.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Oregon</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name></noRegion><name sortKey="Lang, Antony E" sort="Lang, Antony E" uniqKey="Lang A" first="Antony E" last="Lang">Antony E. Lang</name><name sortKey="Liu, Louis W C" sort="Liu, Louis W C" uniqKey="Liu L" first="Louis W C" last="Liu">Louis W C. Liu</name><name sortKey="Visanji, Naomi P" sort="Visanji, Naomi P" uniqKey="Visanji N" first="Naomi P" last="Visanji">Naomi P. Visanji</name></country><country name="États-Unis"><region name="Oregon"><name sortKey="Pfeiffer, Ronald F" sort="Pfeiffer, Ronald F" uniqKey="Pfeiffer R" first="Ronald F" last="Pfeiffer">Ronald F. Pfeiffer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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